The tremendous clinical success of checkpoint blockers illustrates the potential of reestablishing latent immunosurveillance for cancer therapy. A cancer journal for clinicians reaches a diverse group of oncology specialists, primary care clinicians, and other professionals who interact with cancer patients. Pancreatic ductal adenocarcinoma pdac shows remarkable propensity to metastasize. Tumor necrosis factorrelated apoptosisinducing ligand trail has been shown to selectively induce apoptotic cell death in various tumor cells by engaging its deathinducing receptors trailr1 a. In the united states, there were approximately 22,240 new cases of ovarian cancer diagnosed and 14,070 deaths in 2018. As the flagship journal of the american cancer society, ca. Odontogenic tumors ot are considered rare events and their epidemiologic data are scarce and underestimated in developing. International journal of cancer wiley online library. Shimoyama s, gansauge f, gansauge s, kaminishi m, beger hgbasal expression and cytokine induction of intercellular adhesion molecule1 in human pancreatic cancer cell lines. Cdx2 in colorectal cancer is an independent prognostic. International journal of cancer and clinical research. A new cdk9 inhibitor on the block to treat hematologic malignancies, clara alcon, et al.
The omentum, a niche for premetastatic ovarian cancer. Hif2 complex dissociation, target inhibition, and acquired resistance with pt2385, a firstin. Ddr2 facilitates hepatocellular carcinoma invasion and. Kras is one of the most frequently mutated oncogenes in cancer, being a potent initiator of tumorigenesis, a strong inductor of malignancy, and a predictive biomarker of response to therapy. The journal publishes original fulllength research papers in all areas related to experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. American journal of cancer research with official sci impact factor 3. Clinical cancer research is especially interested in clinical trials evaluating new treatments, accompanied by research on. Clinical trials investigating immune checkpoint blockade. Kras oncogenic signaling extends beyond cancer cells to. Mscs are multipotent stromal cells that are known to reside in various. Being closely related to the ar, the glucocorticoid receptor gr has been suggested to play a role in.
Ovarian cancer is progressively accompanied by the accumulation of malignant ascites in the peritoneal cavity containing large numbers of tumorassociated macrophages tams that are usually skewed to alternative polarization m2 and that play an instrumental role in metastatic spread and therapy resistance reinartz et al. Check out new collections focusing on breast cancer, immunotherapy, solid tumors, and gastrointestinal cancer. The journal publishes information about the prevention, early detection, and treatment of cancer, as well as nutrition, palliative care, survivorship, and. Journal impact factor 2015 impact factor list 2015 2014. Cdx2 immunohistochemistry was performed on multipunch tissue microarrays n. The treatment of patients with triplenegative breast cancer tnbc, which lacks estrogen receptor er and progesterone receptor pr expression as well as human epidermal growth factor receptor 2 her2 amplification, is challenging due to the heterogeneity of the disease and the absence of welldefined molecular targets 22,23. Egfr and cox2 protein expression in nonsmall cell lung cancer and the correlation with clinical features journal of experimental and clinical cancer research 2011 30 article mar 2011. This predilection to escape from the primary tumor is driven by paracrine and autocrine mechanisms that guide cancer cells through a multistep process concluding with colonization in distant tissues. Combination of curcumin and bicalutamide enhanced the growth inhibition of androgenindependent prostate cancer cells through sapkjnk and mekerk12mediated targeting nf. The major obstacle in the management of advanced prostate cancer is the occurrence of resistance to endocrine therapy. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells, fibroblasts, cells of the immune system and mesenchymal stem cells mscs. Download citation style files for your favorite reference manager.
Glioblastoma gbm is the most common primary malignant brain tumor in adults and carries a grave prognosis despite advances in surgical resection. Journal of experimental and clinical cancer research impact factor 201819. It is founded by a group of academic physicians and scientists around the world, who are devoted to the. Mskimpact clinical sequencing cohort mskcc, nat med 2017 10945 samples. Ddr2 facilitates hepatocellular carcinoma invasion and metastasis via activating erk signaling and stabilizing snail1. The journal of cancer research and clinical oncology publishes significant and uptodate articles within the fields of experimental and clinical oncology. The applications of the disciplines of pharmacology, immunology, cell biology. Although the androgen receptor ar has been linked to therapy failure, the underlying escape mechanisms have not been fully clarified. American journal of cancer researchopen access journal of. Bailur jk, derhovanessian e, gueckel b, pawelec g 2015 prognostic impact of circulating her2reactive tcells producing pro andor antiinflammatory cytokines in elderly breast cancer patients. In colorectal cancer, cdx2 expression is lost in approximately 20% of cases and associated with poor outcome. Cutaneous squamous cell carcinoma md anderson, clin cancer res 2014 39 samples. Journal of experimental and clinical cancer research. Antoun s, baracos ve, birdsell l, escudier b, sawyer mb.
Journal of clinical and experimental hepatology elsevier. Ijc has a global readership and receives over 3,000 submissions a year under a broad scope of topics relevant to experimental and clinical cancer research. Understanding how cancer cells overcome chemotherapyinduced cell death is critical in promoting patient survival. Ovarian cancer is the most lethal gynecological malignancy, accounting for 2. Cd44 is a biomarker associated with human prostate cancer radiation sensitivity. Opportunities and challenges of radiotherapy for treating cancer. Opportunities and challenges of radiotherapy for treating. Targeting tnfrelated apoptosisinducing ligand trail. International journal of clinical and experimental medicine ijcem issn 19405901, is an open access online journal. Although largely neglected in the clinical practice, accumulating evidence indicates that the efficacy of conventional and targeted anticancer agents does not only involve direct cytostaticcytotoxic effects, but also relies on the reactivation of. The editorinchief is mauro castelli regina elena national. Clinical breast cancer is a part of elsevier s oncology journal network. Chemoresistance is a major factor driving tumour relapse and the high rates of cancerrelated deaths. Dong wang, jingbo bao, kai zhang, longfang ju, lingzhi yu.
The arsenal of treatments for most cancers fit broadly into the categories of surgery, chemotherapy, radiation, and targeted therapy. Ovarian cancer patients experience high mortality rates due to commonly being diagnosed. Sarcopenia in an overweight or obese patient is an adverse prognostic factor in pancreatic cancer. Cancer pain results from changes in skin, bone, nerve, and other tissues due to direct tumor involvement or metastases, treatment effects eg, diagnostic procedures. Combination of curcumin and bicalutamide enhanced the.
A cancer journal for clinicians wiley online library. Immune checkpoint inhibitors have changed the landscape of cancer immunotherapy and are being integrated into the standard of care for a variety of solid and hematologic malignancies. Jcp was launched in june 20 after the title was changed from journal of korean association of cancer prevention from march 1996 to december 2004 and cancer. American journal of clinical and experimental medicine. Jceh publishes outstanding basic and clinical papers on all aspects of liver diseases, including both human and animal studies. Although cellintrinsic features support the metastatic ability of cancer cells. Tumour cell secretome in chemoresistance and tumour. Journal of cancer research and clinical oncology home. Paracrine and cell autonomous signalling in pancreatic. The glucocorticoid receptor is a key player for prostate.
It is the official journal of the regina elena national cancer institute. With clinical breast cancer indexed in pubmedmedline, your published article is guaranteed maximum visibility. Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. Clinical cancer research, is a journal of the american association for cancer research whose focus is to publish innovative clinical and translational cancer research studies that bridge the laboratory and the clinic. Lentiviral vectormediated doxycyclineinducible usp39. Arenavirus as a potential etiological agent of odontogenic tumours in humans. International journal of clinical and experimental medicine lingde kong, zhao liu, fei meng, yong shen. Here, we aim to validate the clinical impact of cdx2 and investigate the role of promoter methylation and histone deacetylation in cdx2 repression and restoration. Journal of experimental and clinical cancer research is ranked in the first quartile of oncology journals in journal citation reports and is the official.
The journal encourages to publish original, novel, and welldesigned. Despite the large investment to understand the effects of kras activation in cancer cells, pharmacologic targeting of kras or its downstream effectors has not yet been. It was established in 1982 and has been published by biomed central since 2008, when the journal joined biomed central. Metaanalysis of massage therapy on cancer pain sook. All represent proven and successful strategies, yet each can trigger local tumor and systemic host processes that elicit unwanted, often opposing, influences on cancer growth. Clinical breast cancer has a 2018 journal impact factor of 2. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. One emerging mechanism of chemoresistance is the tumour cell secretome tcs, an array of protumorigenic factors released by tumour cells. Singlebundle versus doublebundle anterior cruciate ligament reconstruction. Journal of experimental and clinical cancer research impact. Cjcr annual report 2015 in 2015, cjcr has a significant increase of citations. Apart from the regular issues, cjcr published three focused issuesseries on cancer statistics. International journal of clinical and experimental. Pain is the most common complaint among patients with cancer and is experienced by 40% to 90% of patients.